At age 16, Karen gave birth to her eldest child Chantelle. Shortly after she fell pregnant again with a second daughter, although she lost the baby. She nicknamed her unborn baby Lumpty Dumpty when she lost her. Karen thought she would not have any more children but she went on to have five more children by several different fathers.
In December 2017, after Lauren and Abi Branning fell from the roof of the Queen Victoria, Karen, Sharon, Linda, Shirley and Tina can be seen in the stairwell laughing as Mick walks in. He appears angry, and asks if they heard the sirens. Mick tells them that he better make an announcement. He proclaims that there has been an accident, as the police and Keegan Baker walk in.
In January, Karen thinks she has secured a job at the laundrette, however when she turns up she is shocked to discover Masood working there. Mr. Papadopolous tells them that he will give them both a trial - whoever does the best job, gets the job.